LOCATION, LOCATION, LOCATION. Build your Dream Home in South Florida...and be in the most desirable area. NO HOA fees, just peace, and quiet. Owner Financing AVAILABLE. Port St. Lucie is on the east coast of Florida, about 25 miles south of Vero Beach, 47 miles north of West Palm Beach, and halfway between Orlando and Miami. For locals who might want to take a short trip, weekend getaways to the big cities of Jacksonville and Miami are possible on Intestate 95, which sits on the west side of town. The weather here is unbeatable. Expect to receive 285 sunny days a year. During the spring locals enjoy extremely pleasant temperatures. You will love to get out and spend time watching some professional baseball spring training games.